In this Review, we focus on the most recently published observational studies designed to identify predictors of poor outcome and treatment response or failure, and to evaluate the relative and long-term effectiveness of currently used MS treatments. Such observational studies are addressing issues that are otherwise difficult or impossible to study. In the past decade, a growing number of MS databases and registries have started to produce long-term outcome data from large cohorts of patients with MS treated with disease-modifying therapies in real-world settings. Indeed, RCTs are usually conducted in ideal conditions, so can measure efficacy only in restricted and unrepresentative populations. Randomized controlled trials (RCTs) are accepted as the gold standard for assessing the efficacy and safety of any new drug, but conclusions of these trials do not always aid in daily decision-making processes. The complexity of multiple sclerosis (MS) treatment means that doctors and decision-makers need the best available evidence to make the best decisions for patient care. In future, datasets from individual MS databases and registries should be aggregated into big data algorithms to develop new tools that will enable the implementation of personalized medicine Several new statistical methods are available, and continue to evolve, to minimize biases and limitations of real-world observational studies, thereby optimizing their validity and reliability Observational real-world studies are providing insights into predictors of MS treatment response, comparative effectiveness of disease-modifying therapies, and long-term treatment effectiveness that is useful for directing daily clinical practice The combination of increasing worldwide availability of and access to large MS registries and databases and the growing ability to share and analyse large datasets is enabling real-world observational studies to be conducted We want you to know that you are not alone.The repertoire of disease-modifying therapies for relapsing–remitting multiple sclerosis (MS) has broadened greatly in the past decadeĮvidence-based recommendations from randomized clinical trials are insufficient to guide choices between most available MS drugs If you or a loved one have recently been diagnosed with MS, you may not even know where to begin and what this means in terms of the rest of your life. Everyone’s experience with MS is different and these losses may be temporary or long lasting.Ī detailed view of MS-related damage in the central nervous system that results in the varied and unpredictable symptoms of the disease. This interruption of communication signals causes unpredictable symptoms such as numbness, tingling, mood changes, memory problems, pain, fatigue, blindness and/or paralysis. ![]() The exact cause of MS is unknown, but we do know that something triggers the immune system to attack the CNS. The resulting damage to myelin, the protective layer insulating wire-like nerve fibers, disrupts signals to and from the brain. Multiple sclerosis is a disease that impacts the brain, spinal cord and optic nerves, which make up the central nervous system and controls everything we do.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |